Substrate-induced conformational change on example of yeast hexokinase

Here we see a pace-filling model of a hexokinase subunit showing the prominent bilobal appearance of the free enzyme (the C atoms in the small lobe are shaded green, and those in the large lobe are light gray; the N and O atoms are blue and red).

While here is a model of the hexokinase complex with glucose (purple); the lobes have swung together to engulf the substrate.